All education

Muscle Hypertrophy

What the research says about muscle hypertrophy, in plain English, with every original paper linked.

THE STUDIES

4 studies on this topic

2020

Sports Medicine

Effects of Resistance Training on Muscle Size and Strength in Very Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Studied: 22 studies, adults ≥75 (subgroup analysis for 80+)

Across 22 trials in adults 75 and older, resistance training produced meaningful strength and muscle-size gains — including among the 'oldest-old' (80+) — with very few adverse events reported.

2020

Journal of Strength and Conditioning Research

Sex Differences in Resistance Training: A Systematic Review and Meta-Analysis

Studied: Young-to-middle-aged males and females on matched protocols (pooled trials)

Comparing men and women on identical training programs, muscle growth and lower-body strength gains were essentially equal between the sexes — and women actually showed a larger relative gain in upper-body strength.

Sex DifferencesMuscle Hypertrophy

2018

British Journal of Sports Medicine

A Systematic Review, Meta-Analysis and Meta-Regression of the Effect of Protein Supplementation on Resistance Training-Induced Gains in Muscle Mass and Strength

Studied: 49 studies pooled, resistance-trained individuals

Pooling 49 studies, protein supplementation added modest gains in lean mass and strength on top of resistance training, with benefits plateauing around 1.6g per kilogram of bodyweight per day — one reason protein intake matters more with age.

ProteinMuscle Hypertrophy

2017

Journal of Sports Sciences

Dose-Response Relationship Between Weekly Resistance Training Volume and Increases in Muscle Mass: A Systematic Review and Meta-Analysis

Studied: Pooled resistance training studies across training statuses

Across studies, higher weekly set volumes produced greater muscle growth than very low volumes — but the curve flattens. For most people, a handful of hard sets per muscle group, two to three times a week, is plenty.

These summaries are general education, not medical advice. Individual results vary, and research on groups does not replace advice about your body from your doctor.